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FAQ

What is systemic enzyme therapy?

Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce desired healing effects. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system. Their crucial role in normal inflammatory response assists and supports the body in accelerating healing. Exclzyme 2AF is specially formulated for joint health, making it perfect for athletes and sports-related injuries.

What is a systemic proteolytic enzyme?

Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Systemic proteolytic enzymes are responsible for breaking down accumulated protein and waste substances found in the circulatory system and connective tissue. Waste materials produced from inflammation and other biochemical processes can build up, contributing to an abnormal inflammation response, which is accompanied by increased pain. The waste product of specific concern is known as fibrin. Regular systemic proteolytic enzyme use can improve circulation and aid in flushing out these waste products.

 What is fibrin?

Fibrin is a protein-based substance that is needed to help clot one’s blood, playing a substantial role in immune response and healing. When the body responds to injury or chronic inflammation, fibrin is recruited to the damaged area to form scar tissue. Although the body is equipped with plasmin, a naturally occurring enzyme responsible for breaking down excess fibrin, some people are at a disadvantage – as aging occurs, plasmin levels progressively decrease. This actually increases the risk for excessive, undesirable scar tissue formation in the body.

Are systemic enzymes anti-inflammatory drugs?

Although systemic enzymes produce anti-inflammatory effects, they are not considered a drug. Since enzymes are naturally occurring within the body, systemic enzyme therapy is considered supplementation. One difference between systemic enzymes and NSAIDs (Non-steroidal anti-inflammatory drugs) involves the duration of action. While NSAIDs produce short-term pain relief, systemic enzymes can produce long-term alleviation with appropriate use. The largest difference between NSAIDS and systemic enzymes is the mechanism of action and possible side effects. NSAIDs block the production of prostaglandins, which are responsible for inflammation and swelling. However, prostaglandins protect the lining of the stomach, and prolonged use of NSAIDs can reduce this protection and increase the risk of developing ulcers. Conversely, regular use of systemic enzymes has no negative side effects and can actually provide protective effects against excess inflammation.

Why is it important to take Exclzyme 2AF on an empty stomach?

Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Exclzyme 2AFwith food will compromise their absorption, as well as their effectiveness.

Does Exclzyme 2AF have an enteric coating?

Yes, the serrapeptase in Exclzyme 2AF is enterically coated. While similar systemic enzymes may have the same active ingredients, most do not utilize enteric coating. The purpose of enteric coating is to protect the enzyme from the acidic environment of the stomach. High activity level is preserved until the enzymes reach the small intestine, where absorption into the bloodstream takes place. While the enteric coating can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the enteric coating, allowing the enzyme to become active within the bloodstream.

Do you use phthalates in your enteric coating?

At AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our enteric coating. Compared to other commonly used enteric coating agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant, which means that it can most effectively withstand the acidity of the stomach, allowing its contents to be released in the small intestine and absorbed successfully.

Don’t let the name scare you.MAAC is a food-grade compound that is listed as Generally Recognized as Safe (GRAS) by the Food and Drug Administration (FDA). In addition, the Environmental Protection Agency (EPA) conducted various studies and found sufficient information to reasonably conclude that the current use pattern of MAAC will not adversely affect public health or the environment.

Unlike CAP, MAAC is not under regulation by California Proposition 65, which states that the ingredient is found by the state of California to cause cancer, birth defects, or other reproductive harm. In fact, the European Food Safety Authority – an organization that conducted studies which led to the ban of 6 types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as coating agent in food supplements. This conclusion on the safety of MAAC is derived from the findings of well-cited research.

How long should I take Exclzyme 2AF before feeling results?

Since people experience varying ailments and severity of disease, the length of time to include systemic enzymes in your regimen may vary as well. As an overall guideline, it is typically recommended that new systemic enzyme users start off slow. A starter dose is generally one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a therapeutic dose of 3 capsules, 3 times per day. At this point, results may be monitored, and dosage should be adjusted accordingly. Some consumers find their therapeutic dose between 9-12 capsules per day, while others only need 3-6. There are several factors that may affect results and required dosage, including:

Height

Weight

Age

Severity of symptoms

Tolerance

Time of administration (Better absorbed on an empty stomach)

Adherence to regimen

Nutritional state

What if I miss a dose?

Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up,” on one dose - and remember, systemic enzymes are best absorbed on an empty stomach.

Are there any side effects involved with Exclzyme 2AF?

The use of Exclzyme 2AF has not been shown to exhibit detrimental effects, neither long term nor short term. Just as dosage requirements vary, side effects may vary as well. Although gastrointestinal disturbances have been reported by a small percentage of new users, tolerance is maintained once the dosage is adjusted. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, especially if you are currently on blood-thinning medications or if you are pregnant or nursing.

Can I take Exclzyme 2AFwith other systemic enzymes?

Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Products like Exclzyme 2AF and Peptizyme-SP often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.

Can I take Exclzyme 2AF with digestive enzymes?

Although digestive and systemic enzymes arenot contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 90 or 200

Amount Per Serving:                                 % DV

Vitamin C (as Calcium Ascorbate)            60 mg 100%

Vitamin B6 (as Pyridoxine HCl)                7.8 mg 390%

Calcium (as Calcium Ascorbate)              6.7 mg 0.67%


Folate (as Folic Acid)                               400 mcg 100%


Vitamin B12 (as Methylcobalamine)        100 mcg 1667% 

Proprietary Enzyme Blend:            500 mg *

Peptizyme SP EN (Enteric coated Serrapeptase), Proteases, Bromelain, Papain, Amylase, Amino Peptidase and Lipase

Proprietary Herbal Blend:              175 mg *

Amla, Rutin, Grapeseed Extract, Boswellia and Tumeric

*Daily Value (DV) not established

Other ingredients: Microcrystalline cellulose and cellulose (vegetarian capsule)

Directions: Take 1 to 2 capsules three times a day on an empty stomach. In three days, if desired benefit is not achieved, increase to 2 to 3 capsules three times a day. Take capsules at least 30 to 60 minutes before or 2 hours after a meal with 8 oz. of water. Store in cool, dry place with the lid tightly closed. Avoid excessive heat. Keep out of the reach of children.

Caution: If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Not intended for use by persons under the age of 18.